A novel role for the integrin-binding III-10 module in fibronectin matrix assembly.
نویسندگان
چکیده
منابع مشابه
A novel role for the integrin-binding III-10 module in fibronectin matrix assembly
Fibronectin matrix assembly is a cell-dependent process which is upregulated in tissues at various times during development and wound repair to support the functions of cell adhesion, migration, and differentiation. Previous studies have demonstrated that the alpha 5 beta 1 integrin and fibronectin's amino terminus and III-1 module are important in fibronectin polymerization. We have recently s...
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Fibronectin (FN) assembly into a fibrillar extracellular matrix is a stepwise process requiring participation from multiple FN domains. Fibril formation is regulated in part by segments within the first seven type III repeats (III1-7). To define the specific function(s) of this region, recombinant FNs (recFNs) containing an overlapping set of deletions were tested for the ability to assemble in...
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Fibroblasts have cell surface sites that mediate assembly of plasma and cellular fibronectin into the extracellular matrix. Cell adhesion to fibronectin can be mediated by the interaction of an integrin (oL5/3~) with the Arg-Gly-Asp-Ser (RGDS)-containing cell adhesion region of fibronectin. We have attempted to elucidate the role of the otsfll fibronectin receptor in assembly of fibronectin in ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1996
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.133.2.431